Structure of PDB 7uxh Chain F

Receptor sequence
>7uxhF (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
AMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLG
NLVLNLWDCGGLDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMH
YYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRP
LECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVL
LFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEV
RNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLER
3D structure
PDB7uxh Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F G17 G19 K20 T21 S22 T36 R37 A41 T42 H127 K128 D130 L131 S163 I164 W165 G13 G15 K16 T17 S18 T32 R33 A37 T38 H123 K124 D126 L127 S159 I160 W161
BS02 MG F T21 T42 D62 T17 T38 D58
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0043495 protein-membrane adaptor activity
GO:0046982 protein heterodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0006915 apoptotic process
GO:0008104 protein localization
GO:0009267 cellular response to starvation
GO:0010507 negative regulation of autophagy
GO:0031669 cellular response to nutrient levels
GO:0032008 positive regulation of TOR signaling
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034198 cellular response to amino acid starvation
GO:0035556 intracellular signal transduction
GO:0042593 glucose homeostasis
GO:0061462 protein localization to lysosome
GO:0071230 cellular response to amino acid stimulus
GO:0072657 protein localization to membrane
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:1990130 GATOR1 complex
GO:1990131 Gtr1-Gtr2 GTPase complex
GO:1990877 FNIP-folliculin RagC/D GAP

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uxh, PDBe:7uxh, PDBj:7uxh
PDBsum7uxh
PubMed36697823
UniProtQ7L523|RRAGA_HUMAN Ras-related GTP-binding protein A (Gene Name=RRAGA)

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