Structure of PDB 7uvu Chain F

Receptor sequence
>7uvuF (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPIVVEGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESN
KKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAA
GTPGMRHSLPNSRIMIHQPSTDIAIQAEEIMKLKKQLYNIYAKHTKQSLQ
VIESAMERDRYMSPMEAQEFGILDKVLVHPP
3D structure
PDB7uvu Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
ChainF
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OY9 F R78 L79 E82 H116 Y118 W146 V148 L170 R17 L18 E21 H55 Y57 W85 V87 L109
BS02 OY9 F S108 Y138 S47 Y77
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7uvu, PDBe:7uvu, PDBj:7uvu
PDBsum7uvu
PubMed36586405
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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