Structure of PDB 7uix Chain F

Receptor sequence
>7uixF (length=571) Species: 562 (Escherichia coli) [Search protein sequence]
NFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGK
TAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKAL
LKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHD
VRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKT
VNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEAL
TEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFD
MSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAH
PDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNTERKSIGLIHQDNS
TMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKG
VSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANELLFGSLVD
GGQVTVALDKEKNELTYGFQS
3D structure
PDB7uix AAA+ protease-adaptor structures reveal altered conformations and ring specialization.
ChainF
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F K258 Y259 R260 S297 G298 Y540 V541 K88 Y89 R90 S127 G128 Y370 V371
BS02 AGS F R339 R340 R169 R170
BS03 ADP F L188 V218 G219 K220 T221 I357 L18 V48 G49 K50 T51 I187
BS04 AGS F F461 P496 T497 G498 V499 K501 T502 E503 R702 F291 P326 T327 G328 V329 K331 T332 E333 R525
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006979 response to oxidative stress
GO:0034605 cellular response to heat
GO:0043335 protein unfolding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009368 endopeptidase Clp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uix, PDBe:7uix, PDBj:7uix
PDBsum7uix
PubMed36329286
UniProtP0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

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