Structure of PDB 7u22 Chain F

Receptor sequence
>7u22F (length=320) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAG
LYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSL
AKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAIT
RAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDIT
PEKVLEIQQYAREPISLDQTIEGDSQLGDFIEDSEAVVAVDAVSFTLLQD
QLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIES
KTMSKLRHPSRSQVLRDYLD
3D structure
PDB7u22 Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
ChainF
Resolution3.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F D226 V228 R229 L232 G236 N299 R301 L302 F335 D336 K339 Y341 K342 S344 T345 Y346 T348 W349 W350 D20 V22 R23 L26 G30 N93 R95 L96 F129 D130 K133 Y135 K136 S138 T139 Y140 T142 W143 W144
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009415 response to water
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u22, PDBe:7u22, PDBj:7u22
PDBsum7u22
PubMed36222275
UniProtP9WGI1|SIGA_MYCTU RNA polymerase sigma factor SigA (Gene Name=sigA)

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