Structure of PDB 7ta6 Chain F

Receptor sequence
>7ta6F (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
SRTPSDKPVAHVVANPQAEGQLQWLLLANGVELRDNQLVVPSEGLYLIYS
QVLFKGQGCPSTHVLLTHTISRIAYQTKVNLLSAIKSPCQRAKPWYEPIY
LGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB7ta6 Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling.
ChainF
Resolution2.67 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F P8 S9 K11 V13 H15 L57 Y59 Q61 Y119 V123 Q149 Y151 I155 A156 L157 P4 S5 K7 V9 H11 L47 Y49 Q51 Y100 V104 Q130 Y132 I136 A137 L138
BS02 peptide F P8 L157 P4 L138
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ta6, PDBe:7ta6, PDBj:7ta6
PDBsum7ta6
PubMed35613436
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

[Back to BioLiP]