Structure of PDB 7syp Chain F

Receptor sequence

>7sypF (length=262) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

ARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNR
LKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRL
IYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPD
PLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERH
PGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEE
RDKRLAAKQSSG

3D structure

PDB

7syp Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.

Chain

Resolution

4.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	R3 G4 K6 K7 H8 K10 V12 K16 M19 D21 K22 F27 P29 R30 T33 G34 H36 K37 L38 R49 T57 K62 K63 M66 K75 R77 K106 R108 V131 G132 T133 K134 V140 A144 T146 K155 A187 G203 A219 R221 R240 R255	R2 G3 K5 K6 H7 K9 V11 K15 M18 D20 K21 F26 P28 R29 T32 G33 H35 K36 L37 R48 T56 K61 K62 M65 K74 R76 K105 R107 V130 G131 T132 K133 V139 A143 T145 K154 A186 G202 A218 R220 R239 R254

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7syp, PDBe:7syp, PDBj:7syp
PDBsum	7syp
PubMed	35822879
UniProt	G1TA47

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