Structure of PDB 7sr6 Chain F

Receptor sequence

>7sr6F (length=566) Species: 9606 (Homo sapiens) [Search protein sequence]

KPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNS
PVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLIII
DLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTI
CQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVA
NAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKL
LGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEE
KIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKT
FTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAWQ
IGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRCEPLENALTVFTDGS
SNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYV
VQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLP
GPLTKANEQADLLVSS

3D structure

PDB

7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.

Chain

Resolution

2.62 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	F	A334 N354	A314 N334
BS02	dna	F	W38 F73 L85 D87 R89 P103 G104 Q162 G163 L165 N275 F292 L295 R296 P364 H365 S366	W18 F53 L65 D67 R69 P83 G84 Q142 G143 L145 N255 F272 L275 R276 P344 H345 S346
BS03	dna	F	L105 Y194 D196 L240 G241 K253 R257 Q268 K269 G272 W276 V368 K369 T370 Q493 Y519	L85 Y174 D176 L220 G221 K233 R237 Q248 K249 G252 W256 V348 K349 T350 Q473 Y499
BS04	MG	F	D121 L122 D196	D101 L102 D176
BS05	TTP	F	K77 R83 D121 L122 D124 C125 F126 D196 K230	K57 R63 D101 L102 D104 C105 F106 D176 K210

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003964	RNA-directed DNA polymerase activity
GO:0004523	RNA-DNA hybrid ribonuclease activity

	Biological Process
GO:0006278	RNA-templated DNA biosynthetic process

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum	7sr6
PubMed	35771941
UniProt	Q9UQG0\|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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