Structure of PDB 7scr Chain F

Receptor sequence
>7scrF (length=211) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
PNVVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTL
KHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNV
VDFIRITDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLK
VCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLK
PEYAKRYPSKL
3D structure
PDB7scr Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
ChainF
Resolution2.12068 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8QI F I149 D151 T152 G153 T155 K180 Y201 V202 E208 I126 D128 T129 G130 T132 K157 Y178 V179 E185
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0000310 xanthine phosphoribosyltransferase activity
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042301 phosphate ion binding
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7scr, PDBe:7scr, PDBj:7scr
PDBsum7scr
PubMed35175749
UniProtQ38CA1

[Back to BioLiP]