Structure of PDB 7rwi Chain F

Receptor sequence
>7rwiF (length=174) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVVQETLLRAWQ
HPEVIGDTARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQST
PDEVNAALDRLLIADALAQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEG
TVKSRLHYAVRALRLTLQELGVTR
3D structure
PDB7rwi Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
ChainF
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F V25 R28 L31 R32 R50 E56 R63 P64 A67 W68 F70 V72 N75 V22 R25 L28 R29 R47 E53 R60 P61 A64 W65 F67 V69 N72
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rwi, PDBe:7rwi, PDBj:7rwi
PDBsum7rwi
PubMed35175750
UniProtP9WGH5|SIGL_MYCTU ECF RNA polymerase sigma factor SigL (Gene Name=sigL)

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