Structure of PDB 7r3a Chain F

Receptor sequence

>7r3aF (length=411) Species: 39152 (Methanococcus maripaludis)

SNVKDMSLAPSGHLKMEWAKRHMPVLCRIAEEFKNDKPFEGLTIGMALHL
EAKTAILAETLLEGGAKIVITGCNPLSTQDDVAAACVEKGMEVYAWRGET
NEEYYENLNKVLDSNPDIIIDDGADLIFLIHTERTELIGKIMGGCEETTT
GIIRLKSMAEEGALKFPVVNVNDAYTKHLFDNRYGTGQSAMDGIIRTTNL
LIAGKNVVVGGYGWCGRGVASRAAGHGANVIITEVNPIRALEAKMDGFTV
LKMEEAAKIGDIFVTTTGCKDILRMEHFLLMKDGAVLSNAGHFDNEINKN
DLKELSKSVKEARFNIEEYDLGNKKIYLLGEGRLVNLACADGHPCEVMDM
SFANQALSAKFIKENKGKLENEVYEIPYEQDFKIALLKLHSMGADIDELS
PEQRKYLSDWK

3D structure

• PDB: 7r3a Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pyrococcus furiosus in complex with inosine
• Chain: F
• Resolution: 2.53 Å

Enzymatic activity

• Enzyme Commision number: 3.13.1.9: S-inosyl-L-homocysteine hydrolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NOS	F	H70 E72 K74 T75 D143 E168 T169 K198 D202 H313 L355 L358 H364 M369	H49 E51 K53 T54 D122 E147 T148 K177 D181 H292 L334 L337 H343 M348
BS02	NAD	F	T169 T170 T171 N203 G234 W235 C236 T254 E255 V256 R260 T288 I293 A311 G312 N357 H364	T148 T149 T150 N182 G213 W214 C215 T233 E234 V235 R239 T267 I272 A290 G291 N336 H343

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity
• GO:0016802 trialkylsulfonium hydrolase activity

Biological Process

• GO:0006556 S-adenosylmethionine biosynthetic process
• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7r3a, PDBe:7r3a, PDBj:7r3a
• PDBsum: 7r3a
• PubMed: 38548921
• UniProt: Q6LYR8|SIHH_METMP S-inosyl-L-homocysteine hydrolase (Gene Name=ahcY)