Structure of PDB 7pt7 Chain F

Receptor sequence
>7pt7F (length=617) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYI
DYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSTER
VFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTC
DMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRI
QENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLG
LPGVKPSSTLSLGVRDLTYKISFLACHVISIDQEVFLNSLSSDEINELKE
MVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGD
INICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEG
GDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGI
HATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDD
CNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKE
ARSYLVEKYKELRKDDAQRSSYRITVRQLESMIRLSEAIARANCVDEITP
SFIAEAYDLLRQSIIRV
3D structure
PDB7pt7 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
ChainF
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F V797 R798 E801 V576 R577 E580
BS02 ADP F V537 F538 S578 T579 S580 K581 S582 Q583 L727 I731 V319 F320 S360 T361 S362 K363 S364 Q365 L509 I513
BS03 ZN F C311 C338 C150 C177
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:1902969 mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pt7, PDBe:7pt7, PDBj:7pt7
PDBsum7pt7
PubMed35614055
UniProtP53091|MCM6_YEAST DNA replication licensing factor MCM6 (Gene Name=MCM6)

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