Structure of PDB 7p0m Chain F

Receptor sequence
>7p0mF (length=520) Species: 9606 (Homo sapiens) [Search protein sequence]
EKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTR
NYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQ
LRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIK
GHRAMPGKIIQCLKKTKTENPLILIDEVDKDPSSALLELLDPEQNANFLD
HYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAE
RYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLR
KSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWT
AMGGSTLFVETSLRRPKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHA
PANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAM
TGEVSLTGKILPVGGIKEATIAAKRAGVTCIVLPAENKKDFYDLAAFITE
GLEVHFVEHYREIFDIAFPD
3D structure
PDB7p0m A dual allosteric pathway drives human mitochondrial Lon
ChainF
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F A769 W770 T771 P850 K851 D852 S855 A856 A348 W349 T350 P421 K422 D423 S426 A427
BS02 ATP F H491 Y492 P525 V527 G528 K529 T530 Y661 Y673 V709 R710 Q713 H82 Y83 P116 V118 G119 K120 T121 Y240 Y252 V288 R289 Q292
BS03 MG F T530 D590 T121 D176
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0043560 insulin receptor substrate binding
GO:0043565 sequence-specific DNA binding
GO:0051880 G-quadruplex DNA binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0001666 response to hypoxia
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0007005 mitochondrion organization
GO:0030163 protein catabolic process
GO:0032042 mitochondrial DNA metabolic process
GO:0034599 cellular response to oxidative stress
GO:0035694 mitochondrial protein catabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051131 chaperone-mediated protein complex assembly
GO:0051603 proteolysis involved in protein catabolic process
GO:0070407 oxidation-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p0m, PDBe:7p0m, PDBj:7p0m
PDBsum7p0m
PubMed
UniProtP36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)

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