Structure of PDB 7oih Chain F

Receptor sequence
>7oihF (length=571) Species: 9606 (Homo sapiens) [Search protein sequence]
TCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTP
GVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDF
TPEPAANCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSN
ITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNG
RALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREH
NRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMR
KYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNP
RVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLF
EQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRN
LKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLR
DGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSY
PRDFVNCSTLPALNLASWREA
3D structure
PDB7oih Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase.
ChainF
Resolution2.603 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.2.2: myeloperoxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN F F605 K671 F432 K498
BS02 CA F D262 T334 F336 D338 S340 D97 T161 F163 D165 S167
BS03 HEM F M253 G256 Q257 D260 D264 F265 T266 E408 M409 R499 G501 H502 I505 L583 R590 M88 G91 Q92 D95 D99 F100 T101 E235 M236 R326 G328 H329 I332 L410 R417
BS04 8PR F E268 P386 T404 E103 P213 T231
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:7oih, PDBe:7oih, PDBj:7oih
PDBsum7oih
PubMed36048150
UniProtP05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)

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