Structure of PDB 7lun Chain F

Receptor sequence
>7lunF (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
NFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKK
TMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYF
AVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQN
PTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB7lun Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
ChainF
Resolution2.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YFG F H1682 G1683 D1685 Y1701 K1704 N1705 Y1709 Y1714 Y1721 S1722 Y1727 H67 G68 D70 Y86 K89 N90 Y94 Y99 Y106 S107 Y112 BindingDB: IC50=<1000nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7lun, PDBe:7lun, PDBj:7lun
PDBsum7lun
PubMed33838082
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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