Structure of PDB 7k0r Chain F

Receptor sequence
>7k0rF (length=345) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
MSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTL
PVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTI
GVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVK
GLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRN
LQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLH
LLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLL
DDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPK
3D structure
PDB7k0r Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
ChainF
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P F H250 K290 V292 C293 S294 H250 K290 V292 C293 S294
BS02 PO4 F H235 G247 G248 K290 T341 H235 G247 G248 K290 T341
External links
PDB RCSB:7k0r, PDBe:7k0r, PDBj:7k0r
PDBsum7k0r
PubMed33504779
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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