Structure of PDB 7jg5 Chain F

Receptor sequence
>7jg5F (length=464) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
TAGRVVRITGPVVDVEFPRGSVPELFNALHAEITFGALAKTLTLEVAQHL
GDSLVRCISMQPTDGLVRGVEVTDTGASISVPVGDGVKGHVFNALGDCLD
DPGYGKDFEHWSIHRKPPAFSDLEPRTEMLETGLKVVDLLTPYVRGGKIA
LFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELADA
NVLKDTALVFGQMDEPPGTRMRVALSALTMAEFFRDEQGQDVLLFIDNIF
RFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQA
VYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILD
PAIVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARR
IERFLSQNMMAAEQFTGQPGSTVPLKETIEAFDKLTKGEFDHLPEQAFFL
IGGLDDLAKKAESL
3D structure
PDB7jg5 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
ChainF
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K166 E192 R193 T354
Catalytic site (residue number reindexed from 1) K159 E185 R186 T347
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F A162 G163 G165 K166 T167 V168 R193 F343 F422 A155 G156 G158 K159 T160 V161 R186 F336 F415
BS02 MG F K166 T167 K159 T160
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Cellular Component
External links
PDB RCSB:7jg5, PDBe:7jg5, PDBj:7jg5
PDBsum7jg5
PubMed33299175
UniProtA0R200|ATPB_MYCS2 ATP synthase subunit beta (Gene Name=atpD)

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