Structure of PDB 7fs2 Chain F

Receptor sequence
>7fs2F (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
ADVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSII
ATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESF
AGSPLSYRPVAIALDTKGPPGLSEQDVRDLRFGVEHGVDIVFASFVRKAS
DVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGI
EIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVA
NAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELR
RAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAA
VIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKL
RGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
3D structure
PDB7fs2 Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
ChainF
Resolution2.374 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP F L443 T444 T445 T446 S449 W494 R501 G526 R528 G530 S531 G532 Y533 L332 T333 T334 T335 S338 W383 R390 G415 R417 G419 S420 G421 Y422
BS02 OXL F K282 E284 A305 G307 D308 T340 K171 E173 A194 G196 D197 T229
BS03 MG F E284 D308 E173 D197
BS04 O7X F F38 L39 Q405 L406 E409 F28 L29 Q294 L295 E298
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding
Biological Process
GO:0006096 glycolytic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7fs2, PDBe:7fs2, PDBj:7fs2
PDBsum7fs2
PubMed36753880
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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