Structure of PDB 7f3o Chain F

Receptor sequence
>7f3oF (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
SNKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY
KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVID
FSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE
QRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLK
NKWWYDKGECG
3D structure
PDB7f3o Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
ChainF
Resolution1.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0YK F P515 S750 K751 N775 P104 S216 K217 N241
BS02 GLU F Y471 L500 T501 R506 G674 S675 T676 E726 Y60 L89 T90 R95 G140 S141 T142 E192
BS03 ZN F E452 H456 E41 H45
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7f3o, PDBe:7f3o, PDBj:7f3o
PDBsum7f3o
PubMed34267258
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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