Structure of PDB 7d74 Chain F

Receptor sequence
>7d74F (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVI
LAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSET
ADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCE
ADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPI
MAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGI
VGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIG
ESVPEPRIIM
3D structure
PDB7d74 Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
ChainF
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.13: mannose-1-phosphate guanylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F L6 V7 G8 G9 G11 T12 K23 A52 V53 S54 E80 P83 L84 G85 D110 L6 V7 G8 G9 G11 T12 K23 A52 V53 S54 E80 P83 L84 G85 D110
Gene Ontology
Molecular Function
GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0009058 biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0019673 GDP-mannose metabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0120508 GDP-mannose pyrophosphorylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d74, PDBe:7d74, PDBj:7d74
PDBsum7d74
PubMed33986552
UniProtQ9Y5P6|GMPPB_HUMAN Mannose-1-phosphate guanyltransferase beta (Gene Name=GMPPB)

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