Structure of PDB 7c17 Chain F

Receptor sequence

>7c17F (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQE
EILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKM
PKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQI
EEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNR
GLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQA
RTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKV
LKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDV
LAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRK
LRHPSRSEVLRSFLD

3D structure

PDB

7c17 CueR activates transcription through a DNA distortion mechanism.

Chain

Resolution

4.22 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	F	V98 R99 M102 G106 L111 R385 L386 I388 K392 F401 K418 F419 Y425 K426 T429 Y430 T432 W433 W434 Q437 R451 P453 H455 K493 K496 T583 E585 R586 K593	V6 R7 M10 G14 L19 R238 L239 I241 K245 F254 K271 F272 Y278 K279 T282 Y283 T285 W286 W287 Q290 R304 P306 H308 K346 K349 T436 E438 R439 K446
BS02	dna	F	W433 R436 Q437 T440 E458 R465 R562 T572 R584 R588	W286 R289 Q290 T293 E311 R318 R415 T425 R437 R441

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005515	protein binding
GO:0016987	sigma factor activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0009408	response to heat
GO:0010468	regulation of gene expression
GO:0045892	negative regulation of DNA-templated transcription
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0000345	cytosolic DNA-directed RNA polymerase complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:1903865	sigma factor antagonist complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7c17, PDBe:7c17, PDBj:7c17
PDBsum	7c17
PubMed	32989300
UniProt	P00579\|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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