Structure of PDB 7ac8 Chain F

Receptor sequence
>7ac8F (length=198) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
MRIGIISVGPGNIMNLYRGVKRASENFEDVSIELVESPRNDLYDLLFIPG
VGHFGEGMRRLRENDLIDFVRKHVEDERYVVGVALGMQLLFEESEEAPGV
KGLSLIEGNVVKLRSRRLPHMGWNEVIFKDTFPNGYYYFVHTYRAVCEEE
HVLGTTEYDGEIFPSAVRKGRILGFQFHPEKSSKIGRKLLEKVIECSL
3D structure
PDB7ac8 Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
ChainF
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
4.3.2.10: imidazole glycerol-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN F G50 V51 G52 A84 L85 Q88 E96 V140 H141 T142 Y143 G50 V51 G52 A84 L85 Q88 E96 V140 H141 T142 Y143
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0004359 glutaminase activity
GO:0005515 protein binding
GO:0016763 pentosyltransferase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0006541 glutamine metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:7ac8, PDBe:7ac8, PDBj:7ac8
PDBsum7ac8
PubMed33980881
UniProtQ9X0C8|HIS5_THEMA Imidazole glycerol phosphate synthase subunit HisH (Gene Name=hisH)

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