Structure of PDB 7a5y Chain F

Receptor sequence

>7a5yF (length=455) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSAMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
EDYESLPKEVASAKPKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAP
NRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADR
NFTKP

3D structure

PDB

7a5y Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTP alpha S Diastereomers.

Chain

Resolution

2.29 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	T8T	F	K116 I118 D137 R145	K4 I6 D25 R33
BS02	T8T	F	Y155 V156 V378 R451	Y43 V44 V258 R331
BS03	T8T	F	V156 F157 R372 H376 K377	V44 F45 R252 H256 K257
BS04	FE	F	H167 H206 D207 D311	H55 H94 D95 D191
BS05	MG	F	D207 H233	D95 H121
BS06	T8T	F	Q149 L150 R164 H167 D207 A215 H233 D311 K312 Y315 D319 R366 Y374 Q375	Q37 L38 R52 H55 D95 A103 H121 D191 K192 Y195 D199 R246 Y254 Q255
BS07	T8T	F	R333 R352 K354 N358 K523	R213 R232 K234 N238 K397
BS08	T8T	F	V117 N119	V5 N7

External links

PDB	RCSB:7a5y, PDBe:7a5y, PDBj:7a5y
PDBsum	7a5y
PubMed	33988981
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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