Structure of PDB 6y69 Chain F

Receptor sequence

>6y69F (length=177) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFR

3D structure

PDB

6y69 Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

Chain

Resolution

2.86 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	K32 T34 N36 M37 G38 V39 G40 T67 A69 R70 K71 F76 I84 K87 S120 F121 D122 R124 N126 S128 M129 G150 L151 D152 T154	K32 T34 N36 M37 G38 V39 G40 T67 A69 R70 K71 F76 I84 K87 S120 F121 D122 R124 N126 S128 M129 G150 L151 D152 T154
BS02	rna	F	S23 M25 Q62 K63 L65 K68 V88 T89 R91	S23 M25 Q62 K63 L65 K68 V88 T89 R91

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6y69, PDBe:6y69, PDBj:6y69
PDBsum	6y69
PubMed	32601485
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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