Structure of PDB 6xlj Chain F

Receptor sequence

>6xljF (length=476) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]

SEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYP
EAITYLLEQYDRVEAEEARLSDLITGFVDIDPELAREKFAELRAQYVVTR
DTIKHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLI
MKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEV
HRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLV
ISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQ
AITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERM
LMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATT
ESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERI
RQIEAKALRKLRHPSRSEVLRSFLDD

3D structure

PDB

6xlj Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	F	M102 G106 L110 N383 R385 L386 K392 F401 F419 E420 Y425 K426 S428 T429 Y430 W433 W434 Q437 R441 R451 P453 H455 R554 V582 T583 E585 R586 Q589	M14 G18 L22 N246 R248 L249 K255 F264 F282 E283 Y288 K289 S291 T292 Y293 W296 W297 Q300 R304 R314 P316 H318 R417 V445 T446 E448 R449 Q452
BS02	dna	F	N396 R397 R468 I511 G512 D514 R562 T572 L573 R584 E585 R588	N259 R260 R331 I374 G375 D377 R425 T435 L436 R447 E448 R451

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005515	protein binding
GO:0016987	sigma factor activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0009408	response to heat
GO:0010468	regulation of gene expression
GO:0045892	negative regulation of DNA-templated transcription
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0000345	cytosolic DNA-directed RNA polymerase complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:1903865	sigma factor antagonist complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6xlj, PDBe:6xlj, PDBj:6xlj
PDBsum	6xlj
PubMed	33976201
UniProt	P00579\|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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