Structure of PDB 6xh8 Chain F

Receptor sequence

>6xh8F (length=497) Species: 562 (Escherichia coli) [Search protein sequence]

AAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGIN
QVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPEL
AREKFAELRAQYVVTRDTIKAKGRSHATAQEEILKLSEVFKQFRLVPKQF
DYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWF
NAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMS
IGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAV
DKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRI
SRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDED
SHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGID
MNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD

3D structure

PDB

6xh8 Structural basis of copper-efflux-regulator-dependent transcription activation.

Chain

Resolution

4.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	F	V98 M102 G106 L110 N383 R385 L386 K392 R397 E420 R423 Y425 K426 T429 Y430 W433 Q437 R451 P453 M456 D581 V582 T583 E585 R586 K593	V20 M24 G28 L32 N267 R269 L270 K276 R281 E304 R307 Y309 K310 T313 Y314 W317 Q321 R335 P337 M340 D465 V466 T467 E469 R470 K477
BS02	dna	F	R93 Y394 Q437 I443 R465 K502 I511 G512 D513 D516 R562 L573 E574 R584 E585 R588	R15 Y278 Q321 I327 R349 K386 I395 G396 D397 D400 R446 L457 E458 R468 E469 R472

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005515	protein binding
GO:0016987	sigma factor activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0009408	response to heat
GO:0010468	regulation of gene expression
GO:0045892	negative regulation of DNA-templated transcription
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0000345	cytosolic DNA-directed RNA polymerase complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:1903865	sigma factor antagonist complex

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xh8, PDBe:6xh8, PDBj:6xh8
PDBsum	6xh8
PubMed	34113812
UniProt	P00579\|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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