Structure of PDB 6xa2 Chain F

Receptor sequence
>6xa2F (length=399) Species: 529089 (Streptomyces sp. 307-9) [Search protein sequence]
PLELDDAFMQDPHSVYARLNAEGSAHRVMMPPGVPVCGGLPVWLITGYEE
VRSALADPRLSTDLNRTDRLFAQNEPDRNKRGAFSSALATHMLHSDPPDH
TRLRKLVNKAFTSRAIEKLRPEIEQITGELLAALPDEDPVDLLDAFAFPL
PIRVICLLLGVPLNFKSWSKALVSGDSPAATAAASTAMIEYLGDLIERKR
RTPTDDVLAALVSARDVDDRLTETELVSMAFLLFIGGHETTVNTLGNGTL
HLMRNLDQWEALRQDRSLLPGAVEEFLRLESPLKHATFRCATEDLRIGDT
AIPAGDFVLLALASANRDPERFGDPHTLDVRRPTGGHVAFGHGIHYCLGA
PLARMEAQVAFGVLLDTFPAMRLAVDPEDMRWRTSTLIRGLHSLPVRLN
3D structure
PDB6xa2 Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
ChainF
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S186 E251 T252 C359 L360 G361
Catalytic site (residue number reindexed from 1) S174 E239 T240 C347 L348 G349
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM F M100 L101 H108 R112 L244 G249 T252 T299 R301 A351 F352 H357 C359 G361 M92 L93 H100 R104 L232 G237 T240 T287 R289 A339 F340 H345 C347 G349
BS02 V0A F F92 L101 L184 V185 G248 T299 T398 L399 I400 F84 L93 L172 V173 G236 T287 T386 L387 I388
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6xa2, PDBe:6xa2, PDBj:6xa2
PDBsum6xa2
PubMed33569241
UniProtD3Y1J3

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