Structure of PDB 6x34 Chain F

Receptor sequence

>6x34F (length=3715) Species: 9823 (Sus scrofa)

FLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL
AICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTTS
RSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVSV
SSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFH
GHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHL
RWGQPLRIRHVTTGRYLALIEDQGLVVDASKAHTKATSFCFRISKEKLKR
DVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALS
LTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALPLE
GVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLN
CIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCAL
FSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISL
LDKHGRNHKVLDVLCSLCVCNGVAVCSNQDLITENLLPGRELLLQTNLIN
YVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALT
EGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLA
PEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKV
RFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHL
VGPSRCLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYGPV
RDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKA
EDNLRKTKLPKTYMMSNGYKPAPLDAQTTLVDRLAENGHNVWARDRVAQG
WSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIE
RVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADEL
AYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLM
SDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQ
EGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPPCL
RLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGWVT
PDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFVSHTDLV
IGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFE
LGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRV
ETRRAGERLGWAVPLTMMALHIPEENRCMDILELSERLDLQQFHSHTLRL
YRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIH
LESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPPHHF
SAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDPVGG
SVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEEGLLQMKLPES
VKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILMKAF
TMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLLTHC
GIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA
LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMN
NKVFYQHPNLMRALGMHETVMEVMVNVLRFPKMVTSCCRFLCYFCRISRQ
NQRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKVVSYL
AGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANV
VVRLLIRKPECFGPALRLLATIEEAIAIMSFYAALIDLLGRCAPEMHLIQ
AGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTMSASFVPDHKASMVLF
LDRVYGFLLHVLDVGFALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVY
RLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLNVIIP
EKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFS
EKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQ
AMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREK
AQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAEFSVLCRDLYALYPLLIRYVDNNR
AHWLTEPNPSAEELFRMVGEIFIYWSKKHNFKREEQNFVVAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAK
KPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFEEKEME
KQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGN
ADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGEK
VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYL
LRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPC
TGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDM
VVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVG
SEAFQDYVTDPRGLISKKDFQKAAAAAAEFANRFQEPARDIGFNVAVLLT
NLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEIS
ETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEEVQR
VKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPVYYFLEESTGYM
EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYIT
EQPVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAEGLLT
WLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDI
AMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKS
EDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVF
DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSD
YFDTTPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQE
RCWDFFPAGDCFRKQ

3D structure

• PDB: 6x34 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
• Chain: F
• Resolution: 4.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	F	C4959 I4961 H4976 H4981	C3645 I3647 H3662 H3667

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 19:57:58 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6x34', asym_id = 'F', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6x34', asym_id='F', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x34', asym_id = 'F'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x34', asym_id='F')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>