Structure of PDB 6w6h Chain F

Receptor sequence
>6w6hF (length=620) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QALQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEP
GVGKTAIVEGLAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEER
LKAVLDDIKNSAGQIITFIDELHTIVGAGAAGNMIKPMLARGELRLVGAT
TLDEYRKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGVR
ITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDE
VERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQN
EKNAKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQ
KAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLF
DDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTV
VLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTSNLGSG
GSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKR
LAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQQAIGDQLAKMLLA
GQVHDGDTVPVNVSPDADSL
3D structure
PDB6w6h Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
ChainF
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F K250 H643 Y655 V656 K92 H418 Y430 V431
BS02 AGS F P179 V180 P208 G209 K212 T213 A214 I350 P388 P21 V22 P50 G51 K54 T55 A56 I185 P223
BS03 AGS F R571 I573 T609 G610 V611 G612 K613 T614 E615 R805 R808 R346 I348 T384 G385 V386 G387 K388 T389 E390 R580 R583
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0009408 response to heat
GO:0034605 cellular response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6h, PDBe:6w6h, PDBj:6w6h
PDBsum6w6h
PubMed34038719
UniProtP9WPD1|CLPB_MYCTU Chaperone protein ClpB (Gene Name=clpB)

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