Structure of PDB 6vpc Chain F

Receptor sequence
>6vpcF (length=156) Species: 562 (Escherichia coli) [Search protein sequence]
EFSHEYWMRHALTLAKRARDEREVPVGAVLVLNNRVIGEGWNRAIGLHDP
TAHAEIMALRQGGLVMQNYRLIDATLYVTFEPCVMCAGAMIHSRIGRVVF
GVRNSKRGAAGSLMNVLNYPGMNHRVEITEGILADECAALLCDFYRMPRQ
VFNAQK
3D structure
PDB6vpc DNA capture by a CRISPR-Cas9-guided adenine base editor.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna F H57 C87 N108 K110 R111 Y149 R153 Q154 F156 H53 C83 N104 K106 R107 Y145 R149 Q150 F152
BS02 ZN F H57 C87 H53 C83
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0006382 adenosine to inosine editing
GO:0008033 tRNA processing

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Molecular Function

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Biological Process
External links
PDB RCSB:6vpc, PDBe:6vpc, PDBj:6vpc
PDBsum6vpc
PubMed32732424
UniProtP68398|TADA_ECOLI tRNA-specific adenosine deaminase (Gene Name=tadA)

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