Structure of PDB 6v6k Chain F

Receptor sequence
>6v6kF (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELM
TFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSR
PKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMD
DVVDAD
3D structure
PDB6v6k Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.
ChainF
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D837 R841 N842 D855
Catalytic site (residue number reindexed from 1) D137 R141 N142 D155
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QQJ F L718 V726 A743 K745 L788 I789 M790 L792 M793 P794 G796 C797 D800 R841 L844 L18 V26 A43 K45 L88 I89 M90 L92 M93 P94 G96 C97 D100 R141 L144 BindingDB: IC50=<1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6v6k, PDBe:6v6k, PDBj:6v6k
PDBsum6v6k
PubMed32243152
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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