Structure of PDB 6u8k Chain F

Receptor sequence

>6u8kF (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]

EVQLVESGGGLVQPGGSLRLSCAASGFYISYSSIHWVRQAPGKGLEWVAS
ISPSSGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSR
YSRYRRGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLV
KDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ
TYICNVNHKPSNTKVDKKVEPK

3D structure

PDB

6u8k Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.

Chain

Resolution

2.75 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	R22 Q85	R19 Q82	PDBbind-CN: Kd=37nM
BS02	rna	F	Y34 S35 S36 S55 S57 S58 S60 Y62 S102 R103 Y104 S105 R106 R109	Y31 S32 S33 S52 S54 S55 S57 Y59 S99 R100 Y101 S102 R103 R106	PDBbind-CN: Kd=37nM

External links

PDB	RCSB:6u8k, PDBe:6u8k, PDBj:6u8k
PDBsum	6u8k
PubMed	31765566

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