Structure of PDB 6tg9 Chain F

Receptor sequence

>6tg9F (length=493) Species: 1415161 (Rhodobacter capsulatus Y262)

MKIWLPCDAAAKACGAEAVLAALRLEAEKRGGALDIARNGSRGMIWLEPL
LEVETPAGRIGFGPMTPADVPALFDALESHPKALGLVEEIPFFKRQTRLT
FARCGRIEPLSLAQFAAAEGWAGLRKALKMTPAEVVEEVLASGLRGRGGA
GFPTGIKWRTVAAAQADQKYIVCNVDEGDSGSFADRMLIEGDPFCLVEGM
AIAGHAVGATRGYVYIRSEYPDAIAVMRAAIAMAKPFLAEAGFEMEVRVG
AGAYVCGEETSLLNSLEGKRGTVRAKPPLPALKGLFGKPTVVNNLLSLAA
VPWIIAHGAKAYESFGMDRSRGTIPLQIGGNVKRGGLFETGFGITLGELV
EDICGGTASGRPVKAVQVGGPLGAYHPVSDYHLPFCYEQFAGQGGLVGHA
GLVVHDDTADMLKLARFAMEFCAIESCGTCTPCRIGAVRGVEVIDRIAAG
DASAMPLLDDLCQTMKLGSLCALGGFTPYPVQSAIRHFPADFP

3D structure

• PDB: 6tg9 Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase.
• Chain: F
• Resolution: 3.24 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.2: Transferred entry: 1.17.1.9.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	F	G146 R147 G148 N174 D176 E177 Y254 G257 E258 N293 N294 S297	G146 R147 G148 N174 D176 E177 Y254 G257 E258 N293 N294 S297
BS02	SF4	F	S426 C427 G428 T429 C430 C433 L470 C471 G474	S426 C427 G428 T429 C430 C433 L470 C471 G474
BS03	NAI	F	F152 K157 E258 E259 L279 K466 L470	F152 K157 E258 E259 L279 K466 L470

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

External links

• PDB: RCSB:6tg9, PDBe:6tg9, PDBj:6tg9
• PDBsum: 6tg9
• PubMed: 32313256
• UniProt: D5AQH1