Structure of PDB 6qxe Chain F

Receptor sequence
>6qxeF (length=611) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2))) [Search protein sequence]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMRVNKRSYLIRALTLNTMTKDA
ERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAK
LANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPE
WFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYF
NESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRY
TKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKK
SYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIK
NNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWE
QTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPF
VTTHSWIPKRN
3D structure
PDB6qxe Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
ChainF
Resolution4.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna F H32 G33 T34 Y38 K237 R238 M356 K363 R365 H32 G33 T34 Y38 K206 R207 M325 K332 R334
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qxe, PDBe:6qxe, PDBj:6qxe
PDBsum6qxe
PubMed31485076
UniProtP03432|RDRP_I68A6 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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