Structure of PDB 6ow3 Chain F

Receptor sequence

>6ow3F (length=346) Species: 274 (Thermus thermophilus) [Search protein sequence]

SDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEITGLDPDLI
REVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIA
REGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKF
EYKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQ
LQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGDEKDS
FYGDFIPDEHLPSPVDAATQSLLSEELEKALSKLSEREAMVLKLRKGLID
GREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRDFLD

3D structure

PDB

6ow3 Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.

Chain

Resolution

2.766 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	F	I321 F332	I244 F255
BS02	dna	F	D79 V81 R82 L85 G89 L93 N191 R193 L194 S197 K200 F209 K226 F227 E228 R231 F233 K234 S236 T237 Y238 T240 W241	D2 V4 R5 L8 G12 L16 N114 R116 L117 S120 K123 F132 K149 F150 E151 R154 F156 K157 S159 T160 Y161 T163 W164
BS03	rna	F	D323 E324	D246 E247

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0016987	sigma factor activity
GO:0046872	metal ion binding

	Biological Process
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0010468	regulation of gene expression
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6ow3, PDBe:6ow3, PDBj:6ow3
PDBsum	6ow3
PubMed	31965171
UniProt	Q5SKW1

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