Structure of PDB 6oix Chain F

Receptor sequence
>6oixF (length=475) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQKT
QVFPLERAAVRTRLTHSMEVQQVGRYIAKEILSRLKELKLLEAYGLDELT
GPFESIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAERCSVAAL
RLGEEPLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLTWAQVGGILKY
TRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNLALYSRFPLTW
IMEAADDISYCVADLEDAVEKRIFTVEQLYHHLHEAWGSLFSLVVENAWE
KSRDQFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNHALLEDASECS
DLLKLYKNVAVKHVFSHPDVERLELQGYRVISGLLEIYRPLLSLSLSDFT
ELVEKEKRFPIESRLFHKLSTRHRLAYVEAVSKLPSDSPEFPLWEYYYRC
RLLQDYISGMTDLYAWDEYRRLMAV
3D structure
PDB6oix The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity.
ChainF
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H69 H117 D118 D268 R442
Catalytic site (residue number reindexed from 1) H66 H114 D115 D256 R414
Enzyme Commision number 3.1.5.1: dGTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F Q53 V54 H126 K211 K232 Y272 D276 F391 Q51 V52 H123 K199 K220 Y260 D264 F365
BS02 MN F H69 H117 D118 D268 H66 H114 D115 D256
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003924 GTPase activity
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043099 pyrimidine deoxyribonucleoside salvage

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6oix, PDBe:6oix, PDBj:6oix
PDBsum6oix
PubMed31019074
UniProtP15723|DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (Gene Name=dgt)

[Back to BioLiP]