Structure of PDB 6n8o Chain F

Receptor sequence

>6n8oF (length=361) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

SRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYA
VSEKAGHQTSAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFA
PTKTWRKWNVKVNHNEKRYATASAIAATAVASLVLARGHRVEKIPEIPLV
VSTDLESIQKTKEAVAALKAVGAHSDLLKVLKSKKLRAGKGKYRNRRWTQ
RRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPGAHLGRFVIWT
EAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIRP
AGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKP
AAVFTETLKHD

3D structure

PDB

6n8o Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	R31 I34 H36 T40 K44 N45 R47 Q48 Y50 V52 S53 E54 H58 Q59 S61 T67 G68 A70 V71 A72 R73 P75 G81 T82 R84 Q87 N92 M93 C94 R95 R98 M99 F100 A101 P102 K104 R107 K108 K112 N114 H115 N116 K118 R119 R138 R141 K161 T162 K163 L179 K183 K186 L187 R188 A189 G190 K191 K193 Y194 R195 R197 R202 R203 Y209 V216 K217 R220 N221 T227 S232 N234 P240 G241 H243 K271 V272 R300 G303 Q304 A305 Q307 K308 R309 V312 L313 K315 K319 N320 Q322 R326 A331 K332 F334 S341 A344 T347 T349	R30 I33 H35 T39 K43 N44 R46 Q47 Y49 V51 S52 E53 H57 Q58 S60 T66 G67 A69 V70 A71 R72 P74 G80 T81 R83 Q86 N91 M92 C93 R94 R97 M98 F99 A100 P101 K103 R106 K107 K111 N113 H114 N115 K117 R118 R137 R140 K160 T161 K162 L178 K182 K185 L186 R187 A188 G189 K190 K192 Y193 R194 R196 R201 R202 Y208 V215 K216 R219 N220 T226 S231 N233 P239 G240 H242 K270 V271 R299 G302 Q303 A304 Q306 K307 R308 V311 L312 K314 K318 N319 Q321 R325 A330 K331 F333 S340 A343 T346 T348
BS02	rna	F	S53 K193 Y194	S52 K192 Y193

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6n8o, PDBe:6n8o, PDBj:6n8o
PDBsum	6n8o
PubMed	30814529
UniProt	P10664\|RL4A_YEAST Large ribosomal subunit protein uL4A (Gene Name=RPL4A)

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