Structure of PDB 6n55 Chain F

Receptor sequence
>6n55F (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
GEPFLIGVSGGTASGKSSVCAKIVQLLGQNDYRQKQVVILSQDSFYRVLT
SEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAIN
LIVQHIQDILNG
3D structure
PDB6n55 An optimized chemical-genetic method for cell-specific metabolic labeling of RNA.
ChainF
Resolution3.085 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UZ0 F Y65 F114 R174 Y46 F95 R155 PDBbind-CN: -logKd/Ki=7.87,Kd=13.4nM
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0043771 cytidine kinase activity
Biological Process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:6n55, PDBe:6n55, PDBj:6n55
PDBsum6n55
PubMed32015544
UniProtQ9BZX2|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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