Structure of PDB 6msk Chain F

Receptor sequence
>6mskF (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]
EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIK
ENSEKIKVNKTLPYLVSNVIELLDVKCAVIKTSTRQTYFLPVIGLVDAEK
LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQ
IQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQT
KATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTK
RFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLR
SGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA
QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
3D structure
PDB6msk Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP F G189 P229 G230 T231 G232 K233 T234 L235 N333 I365 H369 G393 A394 G145 P185 G186 T187 G188 K189 T190 L191 N289 I321 H325 G349 A350
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043921 modulation by host of viral transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6msk, PDBe:6msk, PDBj:6msk
PDBsum6msk
PubMed30479383
UniProtP17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A (Gene Name=PSMC3)

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