Structure of PDB 6msd Chain F

Receptor sequence
>6msdF (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]
EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIK
ENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVI
KTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKA
MEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVL
MYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL
AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT
QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMN
VSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGI
LEVQAKKKANLQYYA
3D structure
PDB6msd Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP F R344 R347 R320 R323
BS02 ADP F G189 P229 G230 T231 G232 K233 T234 L235 I365 H369 G393 G165 P205 G206 T207 G208 K209 T210 L211 I341 H345 G369
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043921 modulation by host of viral transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6msd, PDBe:6msd, PDBj:6msd
PDBsum6msd
PubMed30479383
UniProtP17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A (Gene Name=PSMC3)

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