Structure of PDB 6mnx Chain F

Receptor sequence
>6mnxF (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGHSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRV
KDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVD
DAFYTLVREIRKHK
3D structure
PDB6mnx KRASQ61HPreferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer.
ChainF
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 K147 G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N113 K114 D116 L117 S142 A143 K144
BS02 MG F S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6mnx, PDBe:6mnx, PDBj:6mnx
PDBsum6mnx
PubMed32605999
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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