Structure of PDB 6lss Chain F

Receptor sequence

>6lssF (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]

VQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPG
RLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQK
IVVKVLKAQ

3D structure

PDB

6lss Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

Chain

Resolution

3.23 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	V2 R4 L5 T6 Y7 R8 R10 L11 S12 Y13 N14 T15 S17 K19 R21 R24 T25 P26 G27 N28 R29 I30 Y32 K40 P42 K43 R54 G55 P61 K62 L64 M65 R66 S68 K69 T70 K72 V74 S75 R76 Y78 G80 R88 R90 R93 A94 I97 E98 K101	V1 R3 L4 T5 Y6 R7 R9 L10 S11 Y12 N13 T14 S16 K18 R20 R23 T24 P25 G26 N27 R28 I29 Y31 K39 P41 K42 R53 G54 P60 K61 L63 M64 R65 S67 K68 T69 K71 V73 S74 R75 Y77 G79 R87 R89 R92 A93 I96 E97 K100
BS02	MG	F	T70 H73	T69 H72

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045296	cadherin binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6lss, PDBe:6lss, PDBj:6lss
PDBsum	6lss
PubMed	32669547
UniProt	P49207\|RL34_HUMAN Large ribosomal subunit protein eL34 (Gene Name=RPL34)