Structure of PDB 6kyv Chain F

Receptor sequence

>6kyvF (length=672) Species: 9606 (Homo sapiens)

KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICK
DLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKL
QELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALK
NWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNIL
IATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSN
AGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQ
PKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRP
HPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVED
IATGVQTLYSKWKDFHFEKIPF

3D structure

• PDB: 6kyv Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs.
• Chain: F
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	Q299 I300 G326 T347 Q349 I350 Q380 H381 Q498 E510 R546 K635 T636 R637 T662 G663 R664 N668 Q678 T697 S698 N720 K750 H830 F853 K858 I875 V886 K888 K907 W908	Q58 I59 G85 T106 Q108 I109 Q139 H140 Q257 E269 R305 K391 T392 R393 T418 G419 R420 N424 Q434 T453 S454 N476 K506 H584 F607 K612 I629 V640 K642 K661 W662
BS02	ZN	F	C810 C813 C864 C869	C564 C567 C618 C623

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6kyv, PDBe:6kyv, PDBj:6kyv
• PDBsum: 6kyv
• PubMed: 31852354
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)