Structure of PDB 6kdy Chain F

Receptor sequence
>6kdyF (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
SFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL
EQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKS
LPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRI
AKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFET
MIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYS
AEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIAD
AVKKVIKVGKVRTSDMGGYATCHDFTEEICRRVKDLDENLY
3D structure
PDB6kdy Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
ChainF
Resolution3.02 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y137 K184 D217 N241
Catalytic site (residue number reindexed from 1) Y124 K171 D204 N228
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F I215 N218 I202 N205
BS02 PE7 F V54 H82 T83 V41 H69 T70
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6kdy, PDBe:6kdy, PDBj:6kdy
PDBsum6kdy
PubMed31515270
UniProtO43837|IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Gene Name=IDH3B)

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