Structure of PDB 6hr2 Chain F

Receptor sequence
>6hr2F (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH
SYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKE
RCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQ
3D structure
PDB6hr2 BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainF
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWZ F F76 W88 Y98 P99 R107 I109 H110 S111 Y112 H115 W117 F16 W28 Y38 P39 R47 I49 H50 S51 Y52 H55 W57
External links
PDB RCSB:6hr2, PDBe:6hr2, PDBj:6hr2
PDBsum6hr2
PubMed31178587
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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