Structure of PDB 6hn5 Chain F

Receptor sequence
>6hn5F (length=323) Species: 9606,559292 [Search protein sequence]
KVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLG
LIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR
QLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL
KTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKE
APYQNVTEFDGQDACGSNSWTVVDIDPPLRQNHPGWLMRGLKPWTQYAIF
VKTLVTFSDERRTYGAKSDIIYVQTDATNYEDSAGECCSCPKTDSQILKE
LEESSFRKTFEDYLHNVVFVPRP
3D structure
PDB6hn5 The signalling conformation of the insulin receptor ectodomain.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D707 H710 N711 F714 V715 P716 R717 D312 H315 N316 F319 V320 P321 R322
BS02 peptide F D496 R498 R539 E706 H710 F714 V715 P716 P718 D187 R189 R230 E311 H315 F319 V320 P321 P323
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6hn5, PDBe:6hn5, PDBj:6hn5
PDBsum6hn5
PubMed30356040
UniProtP03069|GCN4_YEAST General control transcription factor GCN4 (Gene Name=GCN4);
P06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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