Structure of PDB 6hmy Chain F

Receptor sequence
>6hmyF (length=103) Species: 666 (Vibrio cholerae) [Search protein sequence]
TPQNITDLCAEYHNTQIHTLNDKIFSYTESLAGKREMAIITFKNGATFQV
EVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAIS
MAN
3D structure
PDB6hmy Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site.
ChainF
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL F E51 Q61 W88 K91 E51 Q61 W88 K91
BS02 SIA F E11 Y12 H13 E11 Y12 H13
BS03 FUC F T47 F48 H94 T47 F48 H94
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005534 galactose binding
GO:0046812 host cell surface binding
GO:0090729 toxin activity
Biological Process
GO:0035821 modulation of process of another organism
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0042597 periplasmic space
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hmy, PDBe:6hmy, PDBj:6hmy
PDBsum6hmy
PubMed31439922
UniProtP01556|CHTB_VIBCH Cholera enterotoxin subunit B (Gene Name=ctxB)

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