Structure of PDB 6gqw Chain F

Receptor sequence
>6gqwF (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTEDSYRKQVVID
GETCLLDILDTAGAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
VKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGV
DDAFYTLVREIRKHK
3D structure
PDB6gqw Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
ChainF
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F S17 D57 S21 D60
BS02 GNP F G13 G15 K16 S17 A18 V29 D30 Y32 G60 N116 K117 D119 S145 A146 G17 G19 K20 S21 A22 V33 D34 Y36 G63 N114 K115 D117 S143 A144
BS03 F8T F S39 R41 D54 L56 Y71 T74 S42 R44 D57 L59 Y69 T72
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6gqw, PDBe:6gqw, PDBj:6gqw
PDBsum6gqw
PubMed30683716
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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