Structure of PDB 6dm8 Chain F

Receptor sequence

>6dm8F (length=504) Species: 10090,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYKYDIKDVGVDNAGAKAGLTFLVDLIKNKH
MNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQ
PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVA
LKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASG
RQTVDEALKDAQTGSDLYRQSLEIISRYLREQATGSKDAGRRALETLRRV
GDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVT
LISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFV
EFFH

3D structure

PDB

6dm8 Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	F	D-201 K-200 E-104 Y-60 W15	D14 K15 E111 Y155 W227
BS02	GLC	F	D-150 R-149 E-62 P-61 Y-60 W125	D65 R66 E153 P154 Y155 W337
BS03	6AK	F	R229 V230 H233	R432 V433 H436
BS04	6AK	F	H205 A208 F209 M212 M231 F235 N241 R244 T247 F251 I275	H408 A411 F412 M415 M434 F438 N444 R447 T450 F454 I478
BS05	6AK	F	F-123 D-120 A-119 Y-44 I114	F92 D95 A96 Y171 I326
BS06	6AK	F	Y-125 F-123 M106	Y90 F92 M318

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0042981	regulation of apoptotic process
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6dm8, PDBe:6dm8, PDBj:6dm8
PDBsum	6dm8
PubMed	30011190
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); P97287\|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1)

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