Structure of PDB 6ar9 Chain F

Receptor sequence
>6ar9F (length=213) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKT
LKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPN
VVDFIRIVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPAS
LKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFV
LKPEYAKRYPSKL
3D structure
PDB6ar9 Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
ChainF
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E147 D148 D151 Y201 R214
Catalytic site (residue number reindexed from 1) E126 D127 D130 Y180 R193
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3L4 F I149 D151 T152 G153 T155 K180 Y201 V202 E208 I128 D130 T131 G132 T134 K159 Y180 V181 E187 MOAD: Ki=6.54uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0000310 xanthine phosphoribosyltransferase activity
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042301 phosphate ion binding
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ar9, PDBe:6ar9, PDBj:6ar9
PDBsum6ar9
PubMed29481567
UniProtQ38CA1

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