Structure of PDB 6aa8 Chain F

Receptor sequence
>6aa8F (length=279) Species: 272562 (Clostridium acetobutylicum ATCC 824) [Search protein sequence]
KKVCVIGAGTMGSGIAQAFAAKGFEVVLRDIKDEFVDRGLDFINKNLSKL
VKKGKIEEATKVEILTRISGTVDLNMAADCDLVIEAAVERMDIKKQIFAD
LDNICKPETILASNTSSLSITEVASATKRPDKVIGMHFFNPAPVMKLVEV
IRGIATSQETFDAVKETSIAIGKDPVEVAEAPGFVVNRILIPMINEAVGI
LAEGIASVEDIDKAMKLGANHPMGPLELGDFIGLDICLAIMDVLYSETGD
SKYRPHTLLKKYVRAGWLGRKSGKGFYDY
3D structure
PDB6aa8 Crystal structure and kinetic analyses of a hexameric form of (S)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium acetobutylicum.
ChainF
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S117 H138 E150 N188
Catalytic site (residue number reindexed from 1) S116 H137 E149 N187
Enzyme Commision number 1.1.1.157: 3-hydroxybutyryl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F I7 G10 T11 M12 R30 D31 I32 A88 E90 N115 S117 H138 N141 I6 G9 T10 M11 R29 D30 I31 A87 E89 N114 S116 H137 N140
Gene Ontology
Molecular Function
GO:0008691 3-hydroxybutyryl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009056 catabolic process
GO:0019605 butyrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6aa8, PDBe:6aa8, PDBj:6aa8
PDBsum6aa8
PubMed30387779
UniProtP52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Gene Name=hbd)

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